Published Paper Details:

Intrahepatic Cholestasis of Pregnancy (ICP) is a hepatobiliary disorder occurring typically in the late second and third trimesters. It is characterized by pruritus, elevated serum bile acids, and abnormal liver function tests, with potential risks such as preterm birth and fetal demise Prevalence: 0.2 - 2% of Pregnancies. It poses significant maternal discomfort and is associated with adverse perinatal outcomes such as Preterm Birth, Fetal Distress, and Sudden Intrauterine Fetal Demise. The exact etiology is Multifactorial, involving Genetic predisposition, Hormonal Influences, and Environmental factors. From an Ayurvedic standpoint, ICP closely correlates with Pittaja Vyadhi, Yakrut Vikara of Garbhini particularly involving Kamala (jaundice) and Pittaja Kandu (itching), resulting from Pitta Dushti and obstruction of Raktavaha and Pittavaha Srotas. The condition is primarily driven by Agni Mandya and Ama formation, which further exacerbate the accumulation of morbid Pitta in the Yakrita (liver). Ayurvedic management emphasizes Pitta Shamana (pacification of Pitta), Rakta Shodhana (blood purification), and Yakrit Uttejaka (liver stimulation). Dietary modifications focusing on Madhura, Sheeta, and Snigdha qualities, alongside lifestyle practices that reduce heat exposure and mental stress, are crucial to balance Pitta and ensure maternal well-being. Pre-Conceptional administration of Shodhana, Rasayana and adherence to appropriate Pathya may help in preventing the occurrence of Intrahepatic Cholestasis of Pregnancy (ICP).