Published Paper Details:

Background Inflammation is a natural biological response to injury or infection, often characterized by redness, swelling, pain, and heat. While acute inflammation is a protective mechanism, chronic or unmanaged inflammation can lead to discomfort and various skin disorders. Conventional anti-inflammatory medications may produce side effects with long-term use, prompting increased interest in natural and plant-based alternatives. Herbal medicine has long been used in traditional systems for treating inflammatory conditions. Tridax procumbens, a medicinal herb commonly used in Ayurveda and folk medicine, is known for its anti-inflammatory, wound healing, and antimicrobial properties. Turmeric (Curcuma longa), rich in curcumin, is widely recognized for its powerful anti-inflammatory and antioxidant activity. Aloe Vera is a well-established natural skin soother and moisturizer. Essential oils such as eucalyptus oil and peppermint oil are used for their analgesic, cooling, and antimicrobial effects. Ethanol serves both as a solvent for plant extracts and a preservative, while glycerin helps to retain skin moisture and improve the feel of the product. Combining these natural components into a topical spray formulation provides a convenient, fast-absorbing, and non-greasy method for delivering anti-inflammatory and soothing effects directly to the affected area. This formulation is designed to offer a safe, effective, and natural solution for managing minor inflammation, skin irritation, and wounds. Method: The formulation of the anti-inflammatory spray begins with the preparation of the solvent phase. Approximately 60-65 mL of 70% ethanol is poured into a clean, dry beaker, followed by the addition of glycerin, which is mixed gently to ensure uniform blending. Next, the Tridax procumbens extract and turmeric extract are incorporated into the ethanol-glycerin mixture and stirred thoroughly until fully dissolved or uniformly dispersed. Eucalyptus oil and peppermint oil are then added dropwise while continuously stirring to achieve proper emulsification and dispersion. Subsequently, aloe Vera gel is slowly introduced into the mixture with gentle and continuous stirring to maintain a smooth and homogeneous consistency. The total volume is adjusted to 100 mL by adding more ethanol as required. The pH of the formulation is measured and adjusted to a skin-compatible range of 5.5 to 6.0 using either citric acid to lower the pH or sodium bicarbonate to raise it, added drop by drop under monitoring. Finally, the solution is filtered if necessary using muslin cloth or Whatman filter paper to remove any undissolved particles and then transferred into sterile, amber-colored spray bottles for storage and use. Results: The prepared formulation appeared to be green in color, exhibiting acceptable pH and we have also prepared formulation. The result of prepared formulation was compared with marketed Iodex rapid action spray formulation having similar activity. Conclusion: The evaluation test also indicated that the formulation had acceptable pH, evaporation time, spray pattern, spray angle, average weight per dose, and also the bottles passed the MWIT Turkewadi ABSTRACT leakage test. It was further inferred that it is possible to develop safer and equal effective anti-inflammatory spray from the extract of Tridax procumbens and turmeric.