Published Paper Details:

In many cases, chronic rhinosinusitis (CRS) can have a more significant influence on a patient's overall quality of life than other chronic conditions, especially when it comes to physical discomfort and social functioning. The primary symptoms, which include facial pain or pressure, nasal blockage, nasal discharge, and hyposmia or anosmia, have persisted for at least 12 weeks. Herbal remedies have long been utilized extensively in the therapeutic therapy of CRS because available synthetic medications have substantial negative effects. The aim of the current study is to assess the safety and effectiveness of Itrifal Zamani, a Unani compound medication, in treating patients with chronic rhinosinusitis (CRS). The information in this paper comes from a multicentric, open-level clinical investigation that was carried out at the Regional Research Institute of Unani Medicine in Aligarh, India, between 2018 and 2022 on 57 cases of CRS treated with Itrifal Zamani. One-way analysis of variance (ANOVA) viz. Dennett's test was used to statistically analyze the data, and p value of <=0.05 was observed significant. According to the study, the results of the Sino-Nasal Outcome Test-22 (SNOT-22) of CRS patients treated with Itrifal Zamani showed a significant improvement in a number of symptoms, including blowing nose, sneezing, running nose, coughing, post-nasal discharge, thick nasal discharge, ear fullness, dizziness, ear pain/pressure, facial pain/pressure, difficulty falling asleep, difficulty walking up at night, lack of good night sleep, walking up tired, fatigue during the day, decreased productivity, frustrated/restless/irritable, sadness, embarrassments, sense of taste/smell, blockage/congestion of nose, decreased concentration, and overall score. Comparisons of the Lund-Mackay score (LMS) before and after therapy shows a remarkable decrease, according to x-ray PNS results. Also, the study demonstrated that the medicine is safe and non-toxic. CRS patients of larger population of more research are recommended.