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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 14 | Issue 8 | Month- August 2026
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Published Paper Details:
Paper Title
Bioavailability Enhancement of Folic acid by improving solubility
Authors
Ms. Monali B Parbhane, Dr.Amjadkhan A. Pathan
Keywords
folic acid, solubility, permeability, solid dispersion, inclusion complex, Gelucire 50/13, and hydroxypropyl -beta-cyclodextrin, BCS class IV.
Abstract
Folic acid, an BCS class IV essential nutrient, having low solubility and permeability, limiting its bioavailability and therapeutic efficiency. This study aims to enhance folic acid solubility and permeability through solid dispersion and inclusion complex formation utilizing Gelucire 50/13 and hydroxypropyl-beta-cyclodextrin. Solid dispersions of folic acid with Gelucire 50/13 (1:4 ratios) increased solubility by 8.5 fold, respectively. Using HP-?-CD to create inclusion complexes increased permeability by 20-30 fold. These data illustrate the potential of this combination method to considerably increase folic acid solubility and permeability.These results show that this combined method has the potential to greatly improve folic acid solubility and permeability, hence increasing its bioavailability and therapeutic potential.
IJCRT's Publication Details
Unique Identification Number - IJCRT2508060
Paper ID - 291956
Page Number(s) - a499-a526
Pubished in - Volume 13 | Issue 8 | August 2025
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Ms. Monali B Parbhane, Dr.Amjadkhan A. Pathan, "Bioavailability Enhancement of Folic acid by improving solubility", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.13, Issue 8, pp.a499-a526, August 2025, Available at :http://www.ijcrt.org/papers/IJCRT2508060.pdf
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Volume 14 | Issue 8
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August 2026
Volume 14 | Issue 8
Last Date :
31-Aug-2026
Submit Manuscript Online Impact Factor: 7.97 Review Results : Within 02-03 Days Paper Publication : Within 02-03 Days
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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