Published Paper Details:

Heterocyclic compounds have been shown significant uses in the field of biochemistry, medicinal Chemistry, agricultural science etc. They are important in the metabolism of all living cells. They are widely used in designing of pharmaceutical drugs as building blocks. An important heterocyclic compound is phenothiazine which is a tricyclic compound having thiazine nucleus, possesses a wide spectrum of biological activities and is significantly active to central nervous system. Phenothiazines also exhibit potential as anticancer agents. They interact with DNA via complexation. Biological activities of phenothiazines have been ascribed to structural specificity due to a fold along nitrogen -sulphur axis. 1, 4-Benzothiazines are important analogs of phenothiazines and structural specificity of a fold along nitrogen-sulphur axis is also present in these compounds. Derivatives of 1, 4-benzothiazines are highly bioactive and have widespread use in various therapeutic medicines. In the present research work the synthesized compounds have 2, 3-dihydro-1 4-benzothiazine nucleus having a side chain at position 4- forming nitrosourea linkage. Anti -cancer activities of some of derivatives of 4-(N-alkyl/ aryl-N-nitrsoamido)-2, 3-dihydro-1, 4-benzothiazine derivatives have been reported.8-9