Published Paper Details:

Polymeric nanoparticles have emerged as a promising drug delivery system for improving the therapeutic efficacy of pharmaceutical compounds. This review focuses on the formulation, characterization, and evaluation of polymeric nanoparticles as carriers of dapagliflozin for oral administration. Various formulation techniques, including emulsification-solvent evaporation, ionic gelation, nanoprecipitation, and spray drying, have been explored to enhance drug encapsulation efficiency and controlled release. Characterization methods such as particle size analysis, zeta potential, encapsulation efficiency, in-vitro drug release studies, morphological analysis, and Fourier Transform Infrared Spectroscopy (FTIR) play a crucial role in assessing nanoparticle stability and performance. Polymeric nanoparticles offer several pharmacokinetic and therapeutic advantages, including improved bioavailability, sustained drug release, reduced plasma drug fluctuations, and enhanced patient compliance. Despite these advantages, challenges such as large-scale manufacturing, stability concerns, and regulatory hurdles must be addressed. Recent advances in stimuli-responsive nanoparticles, hybrid systems, and surface modifications have further expanded their applicability beyond diabetes management, including cancer therapy, neurological disorders, antimicrobial drug delivery, and vaccine development. This review highlights the potential of polymeric nanoparticles as a transformative drug delivery platform and emphasizes the need for further research to optimize their clinical applications.