Published Paper Details:

Abstract Background of the study: The Human Papillomavirus (HPV) vaccine is a vital preventive measure against cervical and other HPV-related cancers. Despite its proven efficacy, global uptake remains suboptimal due to various social, cultural, and systemic barriers. Objectives: This meta-analysis aims to synthesize global literature to explore public perceptions and identify key barriers influencing HPV vaccine uptake. Methods: A systematic search was conducted across databases including PubMed, Scopus, Web of Science, and Google Scholar for studies published between 2010 and 2024. Inclusion criteria were observational or interventional studies reporting on public perception, attitudes, and barriers to HPV vaccination. Data were extracted and analysed using random-effects modelling and thematic analysis for qualitative synthesis. Results: Thirty-five studies from 23 countries were included, encompassing over 85,000 participants. Positive perception and vaccine acceptance were highest in high-income countries with robust school-based immunization programs. Key barriers included lack of knowledge (72%), fear of side effects (61%), cost (48%), religious or cultural objections (36%), and misconceptions linking the vaccine to sexual activity (54%). Healthcare provider recommendation strongly influenced uptake. Conclusion: Improving awareness, addressing cultural sensitivities, and strengthening healthcare provider communication are crucial to enhancing global HPV vaccine uptake. Multi-level interventions are necessary to overcome these persistent barriers.