Published Paper Details:

In order to find high-efficiency and low-toxic antimicrobial drugs and a novel transition metal triflate as catalyst activity was utilized for the first time to acquire a synthesis of nine new 3-methyl-1,4,8,9-tetrahydro-5H-pyrazolo(4,3:5,6)pyrido[2,3-d]pyrimidine-5,7(6H)-diones derivatives via a one-pot five-component reaction of substituted aromatic and hetero aromatic aldehydes, barbituric acid, ethyl acetoacetate, hydrazine hydrate and ammonium acetate in aqueous alcoholic medium under catalytic condition . The obtained derivatives were confirmed by measure of advanced spectroscopic data viz; 1HNMR, 13CNMR and LCMS. The derivatives were also studied by antimicrobial activity against bacterial as well as fungal strains and also estimated the measure inhibition zone. The methodology is expeditious and furnishes varied advantages like shorter reaction time, energy efficiency, eco-sustainability and work under mild condition