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  Published Paper Details:

  Paper Title

ELUCIDATING THE EFFECT OF TRICLOSAN ON GUT MICROFLORA AND SPREAD OF ANTIBIOTIC CROSS-RESISTANCE

  Authors

  SUNAINA RANJAN GUPTA,  Ashish Sachan

  Keywords

antibiotic resistance, cross-resistance, efflux pumps, gut microbiome, triclosan

  Abstract


Many consumer items, including soap, mouthwash, shower gels, hand-wash, shampoo, deodorants, and antibacterial lotions, contain TCS. TCS is environmentally resistant and persistent due to its aromatic character and significant chlorination. One of the manufactured antimicrobials that is persistent in the environment and a major cause for concern is triclosan. When various species are exposed to TCS, cross-resistance--that is, resistance to TCS followed by resistance to antibiotics--develops. Exposure to TCS can result in a number of negative effects, including endocrine disruption, liver carcinogenesis, liver fibrosis, and antibiotic resistance. Low-dose exposure to TCS exacerbates colon inflammation and colon carcinogenesis linked to the development of colitis, indicating negative consequences of TCS exposure on gut health. Alpha diversity in the gut microbiota of children who were fed breast milk containing TCS was lower than that of children whose TCS levels were undetectable. Children who were fed breast milk containing TCS also showed modulation of abundant species.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2506673

  Paper ID - 289456

  Page Number(s) - f759-f767

  Pubished in - Volume 13 | Issue 6 | June 2025

  DOI (Digital Object Identifier) -   

  Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Cite this article

  SUNAINA RANJAN GUPTA,  Ashish Sachan,   "ELUCIDATING THE EFFECT OF TRICLOSAN ON GUT MICROFLORA AND SPREAD OF ANTIBIOTIC CROSS-RESISTANCE", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.13, Issue 6, pp.f759-f767, June 2025, Available at :http://www.ijcrt.org/papers/IJCRT2506673.pdf

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ISSN: 2320-2882
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ISSN and 7.97 Impact Factor Details


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ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
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