Published Paper Details:

The absorption process is developed in biological systems to deliver necessary organic and inorganic substances into systemic circulation while maintaining bioavailability. Bioavailability issues might be caused by insufficient solubility or permeability. Most chemicals have solubility difficulties. As a result, as chemical science advances, so does the necessity for the creation of pharmaceutical technologies, which vary depending on the medicine. The medicine has relatively low water solubility, which means that it dissolves slowly in the gastrointestinal tract. The oral route is the most desirable and preferred method of giving medicinal medicines because of their systemic effect. Drugs are categorized into four classes according on their solubility under the BCS classification. Various strategies are employed to increase the solubility of poorly soluble medications, including physical and chemical alterations of the drug, as well as additional methods such as particle size reduction, crystal engineering, salt creation, solid dispersion, surfactant application, and complexation. The choice of solubility-improving technology is determined by the drug's properties, absorption site, and dose form requirements.