Published Paper Details:

This study investigates the anti-ulcer activity of the ethanolic extract of Annona squamosa linn (Root) against Aspirin induced and Pylorus ligated ulcers. Gastric ulcer disease is caused by an imbalance between mucosal defense factors and injurious factors, such as acid and pepsin. Ulcers caused by pylorus ligation result from increased gastric acid and pepsin accumulation, leading to auto digestion of gastric mucosa and breaking down the gastric mucosal barrier. NSAIDs are frequently associated with peptic ulcers. The anti-ulcer effect is supported by decreased aggressive factors like gastric volume, decreased free and total acidity, and increased resistance factors like pH. The anti-ulcer agent may protect the mucosa from acid effects by selectively increasing prostaglandins, which have a vital protective role. The mucosal defense mechanism may be due to the epithelial cells of the gastric mucosa, which are impermeable to H+ ions and form a physical barrier. The ethanolic extract of Annona squamosa linn (Root) was evaluated using the aspirin induced ulcer model, showing dose-dependent inhibition percentages of 53.26% and 63.23% compared to the ulcer control. The standard drug Ranitidine HCL (20mg/kg) showed a percentage inhibition of 71.48% when compared to the ulcer control. The study also found that the extract can reduce reactive free radicals that might cause oxidative damage to tissue. It also reduced polymorphonucleur infiltration, TNF expression, and ROS formation in peptic mucosa. The anti-ulcerogenic activity of the extract may add to its beneficial effect against peptic ulcer disorder.