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Ayurveda is one of the oldest traditional heritages of our country, offering deep insights into health and longevity. It acts as a treasure trove of life's healthful wisdom, steering individuals towards the core goals of Ayurveda. The acharyas, or sages, through their careful observations, explore the depths of Ayurveda, sharing invaluable knowledge through their texts. In modern times, the idea of circadian rhythm, or biological clock, has garnered considerable interest, defined as the 24-hour cyclical changes that occur within our bodies and their clinical significance. Notably, this concept is also discussed in our ancient scriptures, which have not been given the acknowledgment they merit. These scriptures describe the cyclical nature of doshas, which vary over time and present different symptoms in the body. The acharyas have prescribed daily, nightly, and seasonal routines based on these doshas, which are vital for sustaining overall health throughout life, with each routine possessing its own clinical relevance. Establishing a daily regimen is essential for health, enabling necessary adjustments in body, mind, and spirit. A well-organized routine supports the balance of Tridoshas. Biological rhythms, including circadian, ultradian, and infradian rhythms, regulate bodily functions in a rhythmic fashion, governed by an internal clock. Each Dosha exhibits daily fluctuations influenced by digestion phases and age. Factors such as a person's age, circadian rhythm, and eating habits play a significant role in human physiology. Disruptions in the circadian rhythm, caused by environmental influences and bodily changes, can lead to various health problems known as circadian rhythm disorders. Agni, which signifies digestion and metabolism, can either foster health when properly managed or become harmful if ignored. Grasping the concept of Agni is crucial for maintaining optimal digestive and metabolic health. Both the physiological and pathological aspects of Agni are explored and highlighted. The importance of jataragni must be recognized, as it is responsible for the initial breakdown of complex food into simpler forms for the body to absorb. A disruption in this Agni can lead to the creation of ama, srotodushtilakshana, and various health complications. A thorough understanding of Agni's fundamental principles is essential for accurate diagnosis and effective treatment selection. Classical Ayurvedic texts detail a recommended daily routine, known as Dinacharya and Ritucharya, which outlines daily and seasonal practices for individuals to achieve optimal health and a balanced lifestyle. The principles of Ayurveda help us identify the most advantageous times for daily activities while keeping Doshic rhythms in an ideal state. To maintain health and prevent disorders related to modern lifestyles, it is crucial to understand the circadian rhythm in Ayurveda, the factors that disrupt it, its pathogenesis, and the suggested strategies for resetting it.