Published Paper Details:

Paclitaxel, a prominent chemotherapeutic agent originally derived from Taxus brevifolia, has garnered extensive scientific and clinical interest due to its unique mechanism of action and broad-spectrum antineoplastic activity. This comprehensive review delves into the fundamental characteristics of paclitaxel, including its physicochemical properties, mechanism of action, and pharmacokinetics. Special emphasis is placed on its distinctive ability to stabilize microtubules, thereby disrupting cell division and inducing apoptosis in cancer cells. The review also explores the challenges associated with paclitaxel's solubility and bioavailability, which have led to the development of novel formulations and delivery systems. Furthermore, it highlights recent advances in analytical techniques used for the qualitative and quantitative assessment of paclitaxel in various matrices. Techniques such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and emerging nanotechnological methods are critically examined. By consolidating insights from recent literature, this review aims to provide a robust foundation for researchers, clinicians, and pharmaceutical developers working on paclitaxel-based therapies or analytical innovations.