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Pulsed drug delivery systems (PDDS) are essentially time-controlled drug delivery devices in which the mechanism controls the lag time independently of external factors such as intestinal motility, pH, enzymes, etc. A pulsatile drug release, in which the drug is delivered rapidly after a predefined lag period, may be advantageous for a variety of drugs or therapies. Drugs are often released either immediately or gradually. Pulsatile drug release systems, however, have drawn more attention in recent years. Many medications or treatments may benefit from a pulsatile drug release, in which the drug is delivered quickly following a predetermined lag time. There are two types of pulse release systems: single-pulse and multiple-pulse. The family of single-pulse systems known as rupturable dose forms is widely used. One such method is pulsatile medication delivery, which promises to help patients with chronic conditions including arthritis, asthma, and hypertension by administering drugs at the appropriate times, locations, and dosages. Systems for pulsatile medication delivery may lead to major advancements in the treatment of several illnesses. Technologies including Pulsincap, Diffucaps, CODAS, OROS, and PULSY Saremarketed. The press coating process is a simple and unique technology that yields tablets with a programmable lag phase and a quick, or rate-controlled, drug release after ingestion, among its numerous advantages. These tablets may be made without the need of specialized coating equipment or solvent. When selecting the best chronopharmaceutical technology, consideration should be given to both production ease and cost-effectiveness.