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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 14 | Issue 3 | Month- March 2026
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Published Paper Details:
Paper Title
Design of Imidazole-Based Derivatives as Potential Candidates Used to treat Breast Cancer
Authors
Solo Lorin, M. Arockia doss, K. Raja
Keywords
Imidazole; MOE ; Docking; ER? inhibitor; Anticancer activity
Abstract
Tetra-substituted imidazole drugs were designed as potential inhibitors against Estrogen receptor ? (ER?) which is a key target for breast cancer therapy. The ADME properties of the designed drugs were analysed using Lipinski's rule of five. Molecular operating environment (MOE), an integrated Computer-Aided Molecular Design Platform, was used to perform the docking study and the analysis of the protein-ligand interaction. The designed drugs displayed a binding energy ranging from -7.15 to -8.53 kcal/mol. Tamoxifen was used as a reference inhibitor against Estrogen receptor ?. Among the 13 designed drugs, the 6-(6-(1H-pyrazol-1-yl)pyridin-3-yl)-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridine-2- carboxamide (10) fulfills the Lipinski's rule of five and showed good binding interaction with the target receptor and can become a potential alternative to the existing ER? inhibitors.
IJCRT's Publication Details
Unique Identification Number - IJCRT2505141
Paper ID - 285060
Page Number(s) - b249-b257
Pubished in - Volume 13 | Issue 5 | May 2025
DOI (Digital Object Identifier) -
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Solo Lorin, M. Arockia doss, K. Raja, "Design of Imidazole-Based Derivatives as Potential Candidates Used to treat Breast Cancer", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.13, Issue 5, pp.b249-b257, May 2025, Available at :http://www.ijcrt.org/papers/IJCRT2505141.pdf
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Volume 14 | Issue 3
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Volume 14 | Issue 3
Last Date :
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Submit Manuscript Online Impact Factor: 7.97 Review Results : Within 02-03 Days Paper Publication : Within 02-03 Days
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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