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ABSTRACT Background: Antimicrobial resistance (AMR) presents a significant global health challenge, contributing to over five million deaths annually worldwide. This study aimed to evaluate antibiotic prescribing patterns and analyze the antimicrobial sensitivity profiles of isolated organisms. Methods:A Prospective observational study was conducted over a six-month period in the Intensive Care Unit (ICU) and surgical departments. A total of 102 patients were included in the study, based on the inclusion and exclusion criteria. Daily clinical evaluations were performed to monitor patient prognosis, and antibiotic-prescribed cases were systematically analyzed during ward rounds to identify trends in prescribing patterns. In addition, microbiological data, such as culture reports and antibiotic sensitivity patterns, were collected and analyzed to determine the effectiveness of various antibiotics against different pathogens. Results:Analysis of antibiotic prescribing patterns revealed that cephalosporins were the most frequently prescribed class (31.6%), followed by carbapenems (18.7%) and penicillins (15.5%). Among the patient samples, 43 cultures exhibited positive microbial growth and were subjected to antibiotic sensitivity testing. Escherichia coli was the predominant isolate, accounting for 48.8% of the total. Sensitivity testing showed that Pseudomonas aeruginosa exhibited the highest sensitivity to netilmicin (67%). E. coli isolates were most sensitive to nitrofurantoin (100%), followed by imipenem (95%) and meropenem (95%). Klebsiella pneumoniae showed 100% sensitivity to cefoperazone/sulbactam, cefepime, imipenem, norfloxacin, and ciprofloxacin. Overall, netilmicin (90%) demonstrated the highest sensitivity across all isolates, followed by cefoperazone/sulbactam (87%) and piperacillin/tazobactam (85%). Conclusion:These findings highlight the critical need for ongoing surveillance and the implementation of antimicrobial stewardship programs to promote the rational use of antibiotics and improve clinical outcomes in critical care and surgical settings.