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ABSTRACT Introduction: Polycystic ovarian syndrome (PCOD) is one of the most common endocrine and metabolic disorders in women of reproductive age. Knowledge of adolescents is a very powerful tool, and the best way to prevent PCOD in future. Healthy life style during adolescence period can prevent the incidence of PCOD and its complications during the adulthood to some extent. A pre experimental study was conducted in 2023, to assess the effectiveness of planned teaching programme on knowledge regarding PCOD among adolescent girls at St. Mary's Higher Secondary School, Irinjalakuda. One group pre test- post test research design was used for the study and thirty samples were selected by using convenient sampling technique. The data was collected by using structured knowledge questionnaire. The study findings revealed that, before the planned teaching programme, only 3.4% adolescents had good knowledge, 60% had average knowledge and the remaining 36.6% had below average knowledge and after the planned teaching programme 6.6% had excellent knowledge and the remaining 93.4% had good knowledge. The mean post test knowledge score 84.6% with standard deviation 1.73 is higher than mean pre-test knowledge score 70% with standard deviation 2.3. The paired t test results showed that, the calculated t value 5.130 is higher than tabulated t value 2.05 at 0.05 level of significance with 29 df, so the research hypothesis H1 is accepted. The chi- square test revealed that there was no significant association between the pre-test knowledge and the selected demographic variables among the adolescent girls.