Published Paper Details:

The development of oral disintegration films (ODFs) as an alternative to conventional oral dosage forms has gained increasing attention due to their convenience and ease of administration. In this study, Ticagrelor FDFs were prepared by the solvent casting method and evaluated using in vitro studies. The prepared formulations showed a uniform distribution of the drug throughout the film and effective release when compared to other formulations by drug release study. The prepared films were found to be homogenous, yellowish in color, and flexible. The results shows that thickness, tensile strength, and the concentration of the film significantly influenced the ODF dissolution time. The surface pH of all the selected formulations was around neutral pH, indicating that there will be no irritation to the oral mucosal cavity. The folding endurance values provide important information about the mechanical properties of ODFs and can help in selecting the most suitable formulation for use. The dissolution test value comparison showed that F2 and F6 are similar in terms of drug release and F5 and F1 have very different drug release profiles. Based on the results, it can be concluded that ODFs have promising potential dosage form for the delivery of Ticagrelor, F2 and F6 were identified as most successful formulation of this study