Published Paper Details:

This review aims to outline intermittent fasting regimens, highlight their health benefits and discover the physiological mechanisms behind to their potential effects. Evidence suggests that improved fasting regimens support weight loss and metabolic health, while reducing nighttime eating and extending fasting periods may enhance overall well-being. Metabolic syndrome (MetS) is increasingly prevalent worldwide, posing significant societal and economic challenges. Given its association with conditions like obesity, cardiovascular disease and type 2 diabetes which also exacerbate periodontal disease effective prevention and management strategies are crucial. Especially, intermittent fasting has emerged as a scientifically supported, non-pharmacological approach with potential therapeutic benefits for metabolic, inflammatory and lifestyle-related diseases. Intermittent fasting may exert its effects through the mechanisms such as circadian rhythm regulation, adipose tissue modulation, gut microbiome alterations and autophagy. Preclinical, epidemiological and clinical studies indicate its potential benefits for metabolic and inflammatory markers. However, evidence on its impact in patients with non-alcoholic fatty liver disease remains limited. Further research is needed to the clarify its mechanisms and evaluate its safety and efficacy in this population. "In that also analysed how fasting and exercise, both individually and together, impact metabolic health and offer insights into potential strategies for preventing metabolic-related diseases."