Published Paper Details:

The development of effective antimicrobial agents is critical in combating bacterial infections, particularly in the face of increasing antibiotic resistance. In this study, we explore the formulation of fraxidin-loaded antimicrobial nanoemulsion gel as a promising therapeutic approach. Fraxidin, a bioactive compound with known antimicrobial properties, has been encapsulated in a nanoemulsion system to enhance its stability, solubility, and bioavailability. The gel formulation was developed by incorporating the fraxidin-loaded nanoemulsion into a suitable gel matrix, designed for topical application. Characterization of the nanoemulsion gel, including particle size, zeta potential, encapsulation efficiency, and in vitro release studies, demonstrated the successful encapsulation of fraxidin and its sustained release profile. Antimicrobial efficacy was evaluated against common pathogens, with the fraxidin-loaded nanoemulsion gel showing significant inhibitory effects, as compared to free fraxidin, indicating an enhanced antimicrobial activity due to the nanoencapsulation. Furthermore, the gel formulation exhibited desirable rheological properties, stability, and skin compatibility, making it suitable for topical application. This research highlights the potential of fraxidin-loaded nanoemulsion gel as a novel, effective, and safe alternative for the treatment of skin infections and other microbial-related ailments. The results of this study contribute to the growing field of nanomedicine, demonstrating the therapeutic advantages of nanoemulsions in drug delivery systems for enhanced antimicrobial action.