Published Paper Details:

Gentamicin, an aminoglycoside antibiotic, is widely used to treat severe bacterial infections but is associated with nephrotoxicity, leading to acute kidney injury due to oxidative stress, mitochondrial dysfunction, and tubular cell damage. This study explores the nephroprotective potential of herbal drugs in mitigating gentamicin-induced renal toxicity. A comprehensive review of various medicinal plants with antioxidant, anti-inflammatory, and cytoprotective properties was conducted. Studies investigating the efficacy of herbal extracts and bioactive compounds in preventing or reducing gentamicin-induced nephrotoxicity were analyzed. Several herbal drugs, rich in flavonoids, polyphenols, and alkaloids, demonstrated significant nephroprotective effects by reducing oxidative stress, inhibiting inflammation, and promoting renal repair. These natural compounds exhibited protective effects by modulating key biochemical markers of kidney function, reducing histopathological damage, and restoring antioxidant enzyme levels. Herbal drugs show promising potential in counteracting gentamicin-induced nephrotoxicity through multiple protective mechanisms. Their integration into therapeutic strategies may offer a safer approach to managing drug-induced renal injury. However, further preclinical and clinical studies are necessary to confirm efficacy, establish standardized dosages, and evaluate long-term safety.