Published Paper Details:

The present study focuses on enhancing the solubility and dissolution characteristics of Aceclofenac, a Biopharmaceutical Classification System (BCS) Class II drug with poor aqueous solubility, using the solid dispersion technique. The study employs two methods: fusion and solvent evaporation, incorporating PEG 6000 and PVP K32 as hydrophilic carriers. Preformulation studies, including FTIR analysis, confirmed no significant drug-excipient interactions, ensuring compatibility. Solid dispersions were prepared and evaluated for micrometric properties, flowability, in vitro drug release, and stability. Results: The results demonstrated a significant improvement in solubility and dissolution rates, particularly with the formulation ASDF3 (fusion method with PEG 6000), which exhibited superior dissolution characteristics compared to ASDS3 (solvent evaporation with PVP K32). Based on in vitro drug release studies, the solid dispersion method effectively improved the dissolution profile of Aceclofenac, highlighting its potential for enhancing the bioavailability of poorly soluble drugs. The findings suggest that polymer selection and preparation method significantly influence the drug's solubility and dissolution behaviour.