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In the india, traditional indian system of medicine AYUSH (Ayurveda, Yoga, Unani, Siddha and Homeopathy ) is widely used from ancient time. Ayurveda is a comprehensive, natural health care system that originated in the ancient vedic times of india. Tinospora Cordifolia is used as ayurvedic formulation from ancient time. The aim of this review article explore about various phytochemical, pharmalogical activities and ayurvedic formulation of Tinospora Cordifolia. Tinospora Cordifolia also called as heart leaved moonseed, amrita, gurbel, giloy or guduchi(in Sanskrit) is a herb of the family Menispermaceace. It is native torrid areas of India, Srilanka, Myanmar, Australia and Africa. It is attracted attention in the last few 10 years becaue whole part of plant like roots, stems and leaves are used in folk medicine and the ayurvedic system of medicine alonen and use in combination with other plant for treating several diseases. Tinospora cordifolia is broadly acknowledge as a important plant in the indian system of medicines due to its biological active componds and has been therapeutic used in disease like diabetes, jaundice, stomachache, urinary promblems, cancer, fever, helminthiasis, leprosy, skin aliments dysentery, prolonged diarrhea and many more. T. cordifolia has a rich sources of phytochemicals that extract used as medicnal properties. Phytochemical present in T. cordifolia is alkaloids, steroids, glycosides, diterpenoid lactones, phenloics, aliphatic compound and polysaccharides.