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Background: As Substance abuse refers to the excessive use of a drug in a way that is detrimental to self, society, or both. 15-24 years age range, 50% of deaths (from accidents, homicides, and suicides) involved. Alcohol is the world's third largest risk factor for disease and contributes to 4% of the global burden of disease. In 2020-21, 66.7 million people in the United States reported binge drinking. Physical dependence caused by long-term drug use is a physiologic state in which withdrawal symptoms develop when the drug is stopped. Psychological dependence is defined as a strong desire to continue using a drug in the absence of physical dependence. Therefore, the current study aims to improve B.Sc. nursing students' knowledge of substance abuse problems by providing them with an educational package. Method: A Quantitative pre-experimental one group pre-test post-test research design was used to conduct the study. A sample of 120 B.Sc. nursing students was selected by using purposive sampling technique. Structured knowledge questionnaire was prepared for data collection and a structured teaching program was delivered about problems of substance abuse. Results: The mean pre test knowledge score was 12.60, whereas mean post test knowledge score was 22.05 with the mean difference of 9.45 and obtained "t" value 30.1841 was significant at 0.05 level. Study provide strong evidence in favour of effectiveness of structured teaching program in increasing B.Sc. nursing student's knowledge level about problems of substance abuse. Discussion: Discussion based on the findings obtained from the statistical analysis and its relation to the objectives of the study, the conceptual framework and the related literature. The aim of the study was to assess the effectiveness of structured teaching program (STP) on knowledge regarding problems of substance abuse among first year B.Sc. nursing students. Conclusion: Study concluded that continue educational intervention is the need of hour in enhancing knowledge level of B.Sc. nursing students regarding problems of substance abuse.