Published Paper Details:

Cancer patients still struggle greatly to control the nausea and vomiting brought on by treatment. Tetrahydrocannabinol and metoclopramide hydrochloride are two less effective traditional antiemetics than phenothiazines. Our findings and those of many pilot trials suggest that high glucocorticoid dosages help reduce the nausea and vomiting that come with cancer therapy. Still, some cancer patients suffer negative side effects from their drugs; the most frequent ones are nausea and numbness. Chemotherapy-induced nausea and vomiting (CINV) may occur gradually or suddenly. After starting chemotherapy, acute emesis manifests 24 hours later; delayed episodes follow and may last over several days. It is recommended to use dexamethasone, aprepitant, a 5-HT3 receptor antagonist, or both as a pretreatment to prevent acute emesis. For delayed emesis caused by moderately to highly emetogenic anticancer medicines, oral dexamethasone, either by itself or in combination with aprepitant, is advised. Oral mucositis makes administering oral antiemetic medications more difficult. It is the cause of dysphagia and other swallowing difficulties in patients with head and neck cancer undergoing radiation and chemotherapy. To aid patients who have difficulty swallowing, jelly formulations and oral dissolving tablets have been developed. Although the insoluble portions of oral disintegrating tablets remain in the mouth until they are taken, they disintegrate quickly and may be a bit uncomfortable to take. Though often hefty, these formulations are helpful for elderly people who have trouble swallowing. Furthermore, dental care products have made use of edible thin oral film formulations that dissolve readily in saliva without the need for water. Particularly helpful are these oral disintegrating thin film formulations for those who have trouble swallowing and eating.