Published Paper Details:

The gut microbiota plays a crucial role in maintaining human health, with its dysregulation linked to various diseases. Piper nigrum, commonly known as black pepper, has been traditionally used in herbal medicine and contains bioactive compounds, particularly piperine, which exhibit significant pharmacological properties. This review explores the therapeutic potential of Piper nigrum in modulating gut microbiota. Key bioactive compounds influence gut health through prebiotic effects, antimicrobial properties, and the restoration of microbial balance during dysbiosis. Piperine also influences gut permeability, anti-inflammatory pathways, and bile acid metabolism, contributing to gut homeostasis. Emerging evidence highlights its role in managing gut-related disorders, including irritable bowel syndrome, inflammatory bowel disease, obesity, neurodegenerative diseases, and colorectal cancer, often through its interaction with the gut-brain axis. While the potential is promising, challenges such as limited clinical trials and bioavailability remain to be explored in detail. Future research should focus on omics-based approaches and targeted delivery systems to optimize therapeutic applications.