Published Paper Details:

Fourier transform infrared spectroscopy (FTIR) spectroscopy provides a unique ability to detect and characterize complex chemicals in many industries, especially in medicine and pharmaceuticals, while reducing waste and reducing the need for extensive modeling or use of hazardous chemicals to minimize environmental damage. This review demonstrates the wide range of ex situ and in situ FTIR applications for species identification, characterization, and quality monitoring. The accuracy of ex situ FTIR spectroscopy in identifying impurities, monitoring crystallization processes, and modifying dosage forms can improve product quality, safety, and performance. In addition, its many capabilities, all based on green screening standards, have contributed to drug development, drug use processes, and quality control. On the other hand, in situ FTIR spectroscopy appears to be a new tool for real-time investigation of drug reactions and processes, monitoring drug release kinetics, crystallization kinetics, and surface contact, and provides valuable information. The combination of ex situ FTIR accuracy and in situ FTIR dynamic capability provides a comprehensive guide to green practices, quality control, and innovation in the pharmaceutical and medical industry. This review describes the widespread use of ex situ and in situ FTIR spectroscopy as a green medicinal chemistry tool in the chemical, pharmaceutical, and pharmaceutical industries. However, more research is needed to unlock the full potential of FTIR and develop new applications that will enhance sustainability in these areas.