Published Paper Details:

Hypothyroidism is a common endocrine disorder that affects various physiological systems, including cardiovascular, pulmonary, and musculoskeletal functions. While the clinical symptoms of hypothyroidism are well understood, its effects on physical activity, cardiac fitness, functional capacity, and health-related quality of life (HRQoL) remain less explored. This review aims to evaluate the relationship between physical activity, cardiac fitness, functional capacity, and HRQoL in patients with hypothyroidism. A systematic search of PubMed, Google Scholar, and ResearchGate was conducted, focusing on studies that assessed these outcomes in patients with hypothyroidism. The findings revealed that individuals with hypothyroidism, including those with subclinical hypothyroidism, exhibit significantly lower physical activity levels, cardiorespiratory fitness, and muscle strength compared to healthy controls. Cardiorespiratory function, as measured by VO2 max, was consistently lower in hypothyroid patients. Pulmonary function tests also showed reduced respiratory capacity in hypothyroid individuals. Additionally, hypothyroidism was associated with diminished HRQoL, particularly in areas related to sleep, social isolation, and general well-being. These findings underscore the need for early diagnosis and management of hypothyroidism to mitigate its negative effects on both physical and emotional health. While thyroid hormone replacement therapy may improve some aspects of physical fitness and HRQoL, further research is necessary to explore the long-term benefits of treatment and to identify the most effective strategies for improving the quality of life in this population.