Published Paper Details:

ABSTRACT: Phytochemical study revealed the presence of several compounds in the roots of Plumbago indica. Carrageenan-induced paw edema can be used to screen for anti-inflammatory agents. The study found that oral administration of the plant reduced hyperalgesia and inflammation.In humans, this nociceptor sensitization usually leads to clinical conditions known as hyperalgesia defined as an increased response to a painful stimulus or allodynia described as pain evoked by non-noxious stimuli. In our study, we have proven that oral administration of aqueous extract of Plumbago indica 30 min before Carrageenan was in grade to reduce hyperalgesia and allodynia significantly at 6 h post- Carrageenan..Edema and pain in the hind paw of animals as a result of Carrageenan -induced inflammation usually limit their motility and cause trouble in using their hind paw. During a Carrageenan -induced acute inflammation event, paw tissue loses normal muscle architecture and shows important amassing of infiltrating inflammatory cells and increased inter-fiber space during physical observation. During our study, we found that oral administration of Plumbago indica decreased infiltrating inflammatory.