Published Paper Details:

The purpose of this study to develop medicated chocolate of Atomoxetine. Atomoxetine is a prescription medicine used in the treatment of attention deficit hyperactivity disorder (ADHD). This medicine helps to modulates the activity of certain chemical messengers in the brain, which increases attention and decreases restlessness. The crucial aspect in formulation of medicated chocolate is to mask the bitter taste of drug. Initially the inclusion complex between Atomoxetine and beta cyclodextrin was prepared by kneading method. Different molar ratio of complex is prepared. Complex was characterized using FTIR spectroscopy, differential scanning calorimetry, % drug release study. Medicated chocolate containing Atomoxetine were prepared using ingredients like cocoa powder, cocoa butter, pharmaceutical sugar, lecithin, dicalcium phosphate, flavor. The initial compatibility studies between drug and excipients were carried out using DSC and FTIR spectra. The concentration of cocoa powder [X1] and cocoa butter [X2] were selected as independent variables. The hardness [Y1] and % CDR [Y2] were selected as dependent variables. The prepared medicated chocolate was evaluated for hardness, in vitro drug release, thickness, weight variation, drug content, moisture content, fat and sugar bloom. The results indicated that concentration of cocoa powder [X1] and cocoa powder [X2] were significantly affected the hardness [Y1] and %CDR [Y2]. Formulation F4 was found to be best formulation with % drug release in 30 min 9%. There was no drastic change in the results of medicated chocolate of an optimized batch at end of one month accelerated stability Study