Published Paper Details:

The present investigation was undertaken with the objective of formulating oral fast dissolving film of the antiemetic drug Domperidone to enhance the convenience and compliance by the elderly and pediatric patients. Domperidone consists antiemetic properties related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. Domperidone is a prokinetic & works on the region in the brain that controls vomiting. It is the best option for healing nausea and it is useful for treating vomiting during journeys. Mouth dissolving films were formulated by the solvent casting technique. Films were formulated using Hydroxy Propyl Methylcellulose (HPMC-E5) as a film forming agent, PEG-400 as a plasticizer. The dependent variables were the Percentage Drug Release in 5 minutes and Folding endurance. The thickness, folding endurance, tensile strength, disintegration time, in vitro drug release and drug content uniformity of the prepared films were evaluated. The high percent drug release of the film at pH 6.8 in phosphate buffer suggests its potential application in treating common cold and rhinitis, where there is a requirement of fast drug bioavailability. The overall results suggested that the prepared Domperidone fast dissolving oral films can be used as an attractive and alternative to the commercial available immediate release and conventional tablets resulting improved patient adherence.