Published Paper Details:

This article presents an in-depth examination of the intricate chemical makeup and several medicinal applications of Madagascar Periwinkle (Catharanthus roseus), a plant that has garnered the interest of researchers and medical experts in the realm of modern medicine. The species, originally native to Madagascar but now distributed globally, acts as an important storehouse of bioactive compounds, namely the alkaloids vinblastine and vincristine. These chemicals have greatly revolutionised the area of cancer treatment, particularly in their efficacy against lymphomas and leukaemias. This study extensively examines the complex chemical constituents of the plant, including terpenoid indole alkaloids, phenolics, and flavonoids. The objective is to elucidate the processes by which these molecules are synthesised and comprehend the factors that influence their formation. Furthermore, this abstract explores the broader therapeutic potential of C. roseus beyond its well-established antineoplastic properties. The paper provides a comprehensive analysis of the most recent scientific studies investigating the plant's qualities in relation to its efficacy in treating diabetes, combating infections, functioning as an antioxidant, and safeguarding the nervous system. It offers a thorough assessment of studies conducted in both laboratory and animal settings. The study examines the challenges and potential of using these phytochemicals in medication development, including the techniques for extracting them, biotechnological approaches to enhance alkaloid production, and the prospect of discovering novel compounds. The aim of this endeavour is to promote more investigation into the untapped therapeutic attributes of Madagascar Periwinkle by incorporating available data and identifying areas that need further examination. The primary objective is to cultivate ground-breaking therapeutic methodologies for a diverse array of human ailments.