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INTRODUCTION: Leprosy or Hansen's disease is a chronic granulomatous disorder that is caused by Mycobacterium leprae. It mostly affects skin and peripheral nerves. The disease has varied clinical and pathological manifestations depending on the immune response of the patient. It still remains as a major public health problem facing India. Nearly, 60% of all world leprosy cases are reported from India. The spectrum of presentation of leprosy is very wide. Histopathology is an important tool, helps in confirming the diagnosis for clinically suspicious cases and helps in exact typing which, in turn, influences treatment plan. AIMS AND OBJECTIVES: To study the histopathology of Leprosy cases and identify different Histological subtypes of leprosy at SBKS MIRC sumandeep vidyapeeth , dhiraj hospital, pipariya, waghodiya, vadodara. METHODOLOGY: A retrospective hospital-based study of clinically diagnosed leprosy cases was conducted over a period of 3 Years (January 2020 to January 2023). Lesional skin biopsies obtained were fixed, processed and stained with Haematoxylin and Eosin (H&E) and Fite - Faraco (FF) staining for demonstrating lepra bacilli. The lesions were classified on microscopy as per Ridley-Jopling classification. RESULTS: A total of 100 cases were studied. Highest incidence was in 3rd decade of life. Males were more affected. Most common clinical feature was loss of sensation. The commonest reported histopathological type was tuberculoid leprosy followed by lepromatous leprosy. The concordance was highest in histoid leprosy, indeterminate leprosy and Type 1 Lepra reaction. Overall FF staining was positive in cases. CONCLUSION: The Histopathological examination plays an important role in making definite diagnosis. It still remains the gold standard for early accurate diagnosis and typing of leprosy. Accurate diagnosis is required for proper treatment, preventing deformities and drug resistance. Histopathology also useful for monitoring treatment response.