Published Paper Details:

Medicinal plants are widely used in the treatment of skin diseases. Topical application of gels at pathological sites offer faster release of a drug to site of action. The poly herbal gel of Curcuma longa, Curcuma caesia and amada showed anti-inflammatory activity in paw edema. Among the three distinct phases of inflammation, the last phase is considered to be the most clinically effective phase to access the anti-inflammatory drugs. It was concluded that the response of PHGs treated group animals in the first phase (1 h) after the post treatment was found to be less effective as compared to standard drug treated animals. It might be possibly due to inadequate release of histamine and serotonin.The anti-inflammatory effect was found to be consistent in the second phase (1-2 h) in all treatment group with maximum effect by standard drug treated animals that possibly indicated the release of phase two mediator. However the PHGs treated group animals at all dose level were found to be effective in phase three (2-3 h), corresponding with the significant release for phase 3 mediators.