Published Paper Details:

This article is prepared to continue the Transdermal patches of pantoprazole studies which was covered in our earlier article published in International Journal for Multidisciplinary Research (IJFMR), Volume 6, Issue 6, November-December 2024, IJFMR240631777. The aim of this study is to evaluate the in vitro drug release characteristics of the transdermal patches of proton pump inhibitor (PPI). An in vitro permeation study was carried out by using Franz diffusion cell using full-thickness abdominal skin of male Wistar rat weighing 200 to 250 g [26]. Pantoprazole is extensively metabolized in the liver, and to overcome these problems the current study was aimed as In-Vitro skin permeability studies of Transdermal patches. In this study different polymers (HPMCE5 with PVPK30 and HPMCE5 with EudragitL100) used in different ratios. Solvent evaporation methods were used to fabricate the transdermal patches [1]. Patches were assessed for In vitro permeation study. The in vitro drug release characteristics of the formulated transdermal patches were studied by using a cellulose acetate membrane. The in vitro skin permeability studies showed that 96.26 % of drug Pantoprazole sodium permeated through the rat abdominal skin in 24h. The kinetic studies were carried out and it was found that all the formulations follow zero-order and the release mechanism of drugs was found to be diffusion rate-limited, Non-Fickian mechanism which was confirmed by Korsmeyer-Peppas model.