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Nursing is adjudged as an arduous job. A strenuous or a stressful job is defined as one when demands do not match the resources, capabilities and needs of an employee. Socioeconomic factors, occupation, day to day scheme of things, tough assignments having strict deadlines and affective disorders have escalated the stress levels in the present day lifestyle. The aim of the study was to assess the effectiveness of body scan meditation on stress among staff nurses working in operation theatre of selected tertiary care hospital of city. Methods : The present study was based on Quantitative research approach with One group pre test post test research design. The population was all staff nurses working in tertiary care hospitals present during the study period. The sample consisted of 80 staff nurses working in tertiary care hospitals. The sampling technique used in this study was Non probability Convenience sampling technique. The Standardized perceived stress scale (SPSS) was used to assess the stress level of staff nurses. The content validity of the tool was done by 13 expert from Department of Mental Health Nursing. The reliability of the questionnaire was done by test retest method. Based on the objectives and the hypothesis the study data were analyzed by using various statistical tests such as frequency, percentage, mean, and standard deviation, t' test, one way analysis of variance (ANOVA) Result : The study result reveals that, 90 % Staff nurses were female. Majority 70 % of the Staff nurses were completed their GNM. 51.20 % of the staff nurses were having above 5 years of experience in operation theatre. In pre test 93.75 % of the staff nurses had moderate stress Whereas in post test 82.50 % of the Staff nurses had low stress. In the pre test the mean of the Stress score obtained by the Staff nurses was 20.73 and in the post test it markedly reduced to 11.52. The Stress of the Staff nurses were reduced after giving Body Scan Meditation. Conclusion : The nurses commonly more prone to get stress while working in hospital, for the reason of work load and shortage of nursing personnel, time pressure, death dying uncertainty of treatment , lack of knowledge in advancement of technology and equipments. The study was carried out to assess the effectiveness of Body Scan Meditation on stress among staff nurses working in operation theatre of selected tertiary care hospital. In the pre test the mean of the Stress score obtained by the Staff nurses was 20.73 and in the post test it markedly reduced to 11.52. The Stress of the Staff nurses were reduced after giving Body Scan Meditation