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Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels (hyperglycemia) either from inadequate insulin synthesis or impaired insulin sensitivity. Diabetes mellitus ranks among the top ten major causes of mortality in the 21st century. By 2045, the International Diabetes Federation (IDF) estimates that almost 783 million persons, or 1 in 8, would have diabetes, representing a 46% rise. Hematological markers, including total white blood cell (WBC) counts, lymphocytes, and neutrophils, have been associated with the onset of type-2 diabetes. Increased white blood cell counts correlate with insulin resistance and pancreatic beta-cell impairment. Lagerstroemia speciosa, a tropical and subtropical species indigenous to Asia, is a viable contender for the Western Ghats, a biodiversity hotspot in India, especially around Coimbatore. The experimental animals were divided into six groups with n=6 animals. The groups III, IV, V, and VI are the experimental groups, orally fed with LELE Low Dose and High Dose (250 and 500 mg/kg body weight), and the II the standard groups treated with glibenclamide. The after 21st day evaluated for the estimation of biochemical parameters and haematological parameters. A histopathological evaluation was also performed. The results show that the treated groups showed a significant (***P<0.001, **P<0.01, *P<0.05) elevation compared to the control group. Effective diabetes management frequently necessitates regular complete blood counts, illustrating the need of early identification and management of anemia and obesity in diabetic patients in primary care environments. Plants provide an appropriate substitute to manufactured pharmaceuticals, acting as possible sources of hypoglycemic drugs. Conventional medicinal systems extensively utilize these botanicals for diabetes prevention. Herbs, such as the decorative and medicinal herb L. speciosa, have demonstrated potential antidiabetic properties. Furthermore, anthocyanins, which are polyphenolic substances present in food, may significantly contribute to the prevention of type-2 diabetes.