Published Paper Details:

Contributing predominantly to both acute and chronic disease affecting the liver, drug-induced liver injury leads to higher morbidity and mortality cases. This extensive review paper presents an in-depth analysis about knowledge state on DILI related to its pathophysiology, clinical presentations, diagnostics troubles and treatment strategies. The review of the literature shows that DILI is a complex condition, involving pharmacological, environmental, and genetic variables. The clinical appearance may vary widely from slight increases in liver enzymes to severe liver failure. The time interval between drug intake and the onset of symptoms also varies greatly. This review focuses on the strong need for early DILI diagnosis and treatment to avert liver failure and promote prognosis. We also take into account contemporary diagnostic modalities and treatment strategies, which may include imaging studies, liver biopsies, and biomarkers. This research, therefore, calls for basic scientists, pharmacologists, and clinicians to tackle DILI in a multidisciplinary approach. To enhance better understanding of this complex phenomenon and to encourage further study in this area, this paper attempts to present a comprehensive overview of DILI.