Published Paper Details:

Abstract: sleep deprivation refers to the condition of not having enough sleep, either due to lack of opportunity to sleep or difficulty in falling asleep. It can lead to various cognitive, emotional, and physical impairments, impacting overall health and well-being. Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and impaired daily functioning. AD represents a significant global health concern, yet despite extensive scientific endeavors, effectively treating AD remains an ongoing challenge. Sleep plays crucial roles in the processes of learning and consolidating memories. Research indicates that sleep deprivation and insomnia have been linked to the Pathogenesis of Alzheimer's Disease. Sleep deprivation has been found to increase Amyloid beta deposition and tau hyperphosphorylation, both of which are implicated as risk factors in the pathogenesis and progression of Alzheimer's Disease. Understanding the molecular mechanisms linking sleep deprivation to AD is imperative, as it could pave the way for the development of preventive and therapeutic interventions for the disease. This review explores the intricate relationship between sleep disruption, insomnia, and the pathogenesis of Alzheimer's Disease. It delves into the bidirectional influence of sleep disturbances and AD pathology, highlighting the potential mechanisms linking these phenomena. Understanding these connections is crucial for developing preventive and therapeutic strategies for AD.