Published Paper Details:

Introduction: Amlapitta, an Ayurvedic disorder associated with Pitta Dosha imbalance, manifests as hyperacidity, nausea, and indigestion due to weakened Agni, the digestive fire. This leads to the formation of Ama, an incompletely digested, toxic by-product obstructing the Srotas. Modern medicine finds parallels with gastrointestinal disorders like GERD, where gut dysbiosis, an imbalance of gut microbiota, disrupts digestion, mimicking Ama-related symptoms. Primary objective: To explore the relationship between Ama formation and gut dysbiosis. Literature Review: This research examines the connection between Ama formation and gut dysbiosis, exploring microbial mechanisms contributing to digestive dysfunction in both frameworks. Ayurvedic sources on Agni and Ama are compared to modern studies on the microbiome's role in gut health. Ayurvedic and modern perspectives show significant overlap, with both identifying weak digestion as a core issue leading to toxin formation. In Ayurveda, Ama obstructs Srotas and causes inflammation, while in Western science, gut dysbiosis increases gut permeability and promotes systemic inflammation. Additionally, both systems emphasize diet's role in maintaining a balanced digestive environment to prevent toxin build-up. Discussion: The correlation between Ama and gut dysbiosis reveals shared pathophysiological pathways--both impair digestion, cause inflammation, and encourage toxin formation. Ayurveda's Agni aligns with the microbiome's regulatory role, where strong digestive fire or microbial balance prevents toxic accumulation. Conclusion: Understanding the link between Ama and gut dysbiosis fosters a comprehensive approach to gastrointestinal health, integrating Ayurvedic and modern insights. Future research on microbial profiles associated with Ama and gut health could inspire innovative interventions for conditions like Amlapitta.