Published Paper Details:

The malaria disease is critical because it is caused by the Plasmodium species and transmitted by infected mosquitoes. Prompt and accurate diagnosis plays a major role in reducing the transmission of malaria and controlling severe cases, enabling proper treatment policies. [1], [2]. While the classical approaches require microscopy, molecular techniques such as PCR and LAMP offer increased sensitivity but are mostly out of reach in resource-constrained settings due to their complexity [3]. The designed paper-based microfluidic device was found to function with malaria DNA. The above-designed aim has been achieved by the integration of a lateral flow strip, which makes DNA amplification happen in an uncomplicated, inexpensive, and portable manner. We used the oriented Finite Element Method to simulate the optimised regions in the microfluidic device that capture the DNA followed by a washing and reaction process [4]. These tests were conducted at the laboratory scale using samples of blood, washing buffer Tris, and TE buffer. The experiment did efficiently demonstrate the capability for efficient capillary flow, fluid management, and accurate DNA amplification, the promise of paper-based devices in enhancing diagnostic tools within a resource-constrained environment [5], [6].