Published Paper Details:

Transdermal drug delivery system is the system in which the delivery of the active ingredients of the drug occurs by means of skin. Transdermal distribution establishes the most important channels for a revolutionary medication delivery method. Basically, the Transdermal drug delivery system is a non-invasive method of drug administration. The drug delivery method will incorporate the drug to be delivered into polymeric membranes, which then diffuse the drug into skin at planned and controlled rate. The various advantages of drug delivery of transdermal are oral and injection. Transdermal administration entails to pushing the patch containing a medicinal substance onto the skin, which is both convenient and painless, as well as therapeutic first-pass metabolism. From throughout the body, an adhesive patch is designed to deliver a specific dose of medication into the bloodstream and through the skin. The Transdermal drug delivery has several advantages over other routes of administration, and for some instance, its less invasive, patient-friendly, and it is able to do the bypass of first-pass metabolism and the destructive acidic environment of the stomach that will occurs upon the oral ingestion of drugs. For decades, the transdermal patches were used to deliver drugs such as nicotine, nitroglycerin, fentanyl and clonidine to treat various diseases or conditions. The goal of this review is to know the history and origination of the transdermal patches, the design and usage of medical patches in transdermal drug delivery, with a focus on the recent advances in the innovation and technology that led to the emergence of smart, dissolvable/biodegradable, high-loading/release, as well as 3D-printed patches.