Published Paper Details:

Hepatocellular carcinoma (HCC) is a serious global health concern that is a lethal disease with few viable treatment options. The potential use of natural chemicals in preventing and treating cancer has been brought to light by recent studies. Because of its immunomodulatory qualities, Coccinia grandis, an old medicinal herb, is a serious contender. An overview of current research on the functions of Coccinia grandis 50 bioactive compounds were listed and its active ingredients in the prevention and management of HCC is given in this article. We look at the plant's bioactive ingredients, like flavonoids and cucurbitacins, which have been shown to have anti-cancer properties through a variety of pathways, including immune response regulation, tumor growth reduction, and apoptosis induction. The review also covers the molecular processes involved, such as the upregulation of antioxidant defenses and the inhibition of inflammatory cytokines. We also go over Coccinia grandis's pharmacological challenges and potential therapeutic applications for the management of HCC. By integrating data from preclinical and clinical trials, this review seeks to provide a comprehensive understanding of the potential applications of Coccinia grandis as an additional strategy in HCC therapy. It also highlights the need for more investigation to ascertain this treatment's safety and therapeutic efficacy.