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Abstract - Ayurveda describes a condition called Gridhrasi, or sciatica in modern medical parlance, which refers to discomfort and pain along the sciatic nerve pathway. The word "Gridhrasi" refers to a condition where pain metaphorically travels down the leg like the talon of a vulture. It is derived from the Sanskrit words "Gridhra" (vulture) and "Asi" (pain). In Ayurvedic medicine, it is one of the Vata-related disorders.Because sciatica is characterized by pain or discomfort related to the sciatic nerve, the disease is most similar to sciatica. The patient arrived with paraesthesia and numbness in addition to lower back pain that was radiating to both legs. Acharya's treatment in various texts focuses on Agnikarma. Agnikarma therapy relieves pain, inflammation, and stiffness by applying pressure to the affected areas. Internal medicine and Panchakarma treatments are excellent ways to treat Gridhrasi. The 44-year-old female patient in this case study had Panchakarma treatment (Agnikarma) after exhibiting clinical signs of Gridhrasi.