Published Paper Details:

Objective The objective of this study was to investigate the bioactive compounds present in Tridax procumbens leaves and to evaluate their potential antipsychotic properties. Significance The study is noteworthy since it investigates a natural substitute for the administration of antipsychotics.There is considerable interest in discovering safer and more effective natural chemicals as traditional antipsychotics can have severe adverse effects.An accessible plant called Tridax procumbens may provide a new way to treat psychotic symptoms. Methods To acquire the bioactive components, the leaves of Tridax procumbens were extracted using suitable solvents, such as methanol. To identify and measure the different bioactive chemicals present in the extracts, chromatography techniques (e.g., HPLC, GC-MS) were employed in the analysis process. To identify their probable interactions and modes of action, the discovered compounds were docked with target proteins involved in psychotic symptoms (e.g., monoamine oxidase, NMDA receptor, serotonin receptor , 2 Dopamine receptor). Result The leaves of Tridax procumbens are rich in bioactive substances, such as akuammidine and kaempferol. By affecting the PI3K/Akt pathway, blocking monoamine oxidase, and interacting with NMDA and serotonin receptors, these substances may have antipsychotic effects.