Published Paper Details:

Safety pharmacology is a fast-growing field that generates data to support risk/benefit analysis using the fundamentals of pharmacology in a regulatory-driven manner. The identification of an adverse effect liability, data projection for the safety margin computation, and clinical safety monitoring are the three main concerns for safety pharmacology. Man's breathing is impacted by many medicines. After they are administered, the respiratory system is either directly affected, or a central, metabolic, or vascular action results in alterations in respiratory function. These guidelines suggest that the first investigations be conducted on conscious, unrestrained animals, with a single dose of the medication being given in most cases. Plethysmography in guinea pigs or rats is the most effective method for studying the impact on respiratory function. It is possible to distinguish between medications that change lung mechanical properties and those that impact respiratory control by measuring the ventilatory parameters of resistance, inspiratory time, expiratory time, peak inspiratory flow, and peak exploratory flow. Studying how these medications affect pathogenic animals' respiratory systems is therefore highly beneficial.