Published Paper Details:

: Diabetes mellitus is one of the most serious health challenges confronting the world today, with its prevalence and associated mortality increasing. Poor blood sugar regulation is hazardous to one's health. Traditional anti-diabetic drugs are effective, but they have unavoidable side effects. Groundnuts and seeds, on the other hand, can provide an alternative supply of anti-diabetic drugs. Groundnuts and seeds can be highly useful to folks. They have a low glycemic index, which means they cause blood sugar levels to rise more slowly than high-glycemic foods. This can aid with blood sugar control. They're high in Fiber and healthy fats, both of which can help with blood sugar regulation. The antioxidant and alpha-amylase inhibitory activities of groundnut and seed extracts were determined using the 3,5-dinitrosalicylic acid method and the diphenyl-2-picrylhydrazyl assay model, respectively. Tamarind seeds and almonds had the highest percentage inhibition (76.40% and 71.3%, respectively). Flaxseed had a moderate amount of enzyme inhibition of 54.0%, whereas Walnut had the lowest level of enzyme inhibition of 46.8%. The Glucose Yeast Uptake Model was used to compute the percentage increase in glucose uptake, which was highest in flaxseeds (76.0%) and tamarind (72.3%), 56.4% in almond, and lowest in walnut (40.4%). To learn more about the nature of the samples, the Phytochemicals test was done on all of them. Alkaloid, Tannins, Steroid, Protein, and Carbohydrate were all positive, meaning they were present in all four samples. Flavonoids were found in flaxseeds and tamarind seeds. Saponins and Phlobatannin were only found in Almond. Keller Killani Test was positive for Almond and Tamarind seeds. The phenolics test was used to determine the unknown value for samples, and the results were as follows: Almond 75.88mg/ml, Walnut 85.57 mg/ml, Flaxseeds 85.57 mg/ml, and Tamarind Seed 77.55 mg/ml. Tamarind and flaxseeds were found to be significantly more active than other samples in vitro, however each sample has its own variance and effectiveness. The in-silico molecular docking method was used to determine the efficiency of the samples, and the samples were docked with Human Receptor Protein GLP 1 and the ligand of each sample.