Published Paper Details:

The buccal region of the oral mucosa offers an effective pathway for systemic drug delivery. Medications administered through the oral mucosal layer bypass the gastrointestinal tract, which often has a high first-pass metabolism and can degrade drugs. The buccal drug delivery system allows for direct absorption into the systemic circulation, enabling painless administration, rapid enzymatic action, high bioavailability, and reduced liver metabolism. However, oral drug delivery routes are often limited by significant presystemic metabolism, which can lead to drug breakdown in acidic environments due to poor absorption. Buccal delivery is an appealing option because it allows for easy administration through the buccal mucosal membrane lining the oral cavity. This review paper provides a comprehensive overview of the oral mucosa, mucoadhesion, factors influencing the process, assessment methodologies, and strategies for overcoming challenges in formulating buccal drug delivery systems.