Published Paper Details:

Herbal nail lacquer is a type of nail polish formulated with natural, plant-based ingredients. the utilization of herbal extracts, essential oils, or other natural compounds. Onychomycosis is an infection of the nail due to fungi that include dermatophytes, non-dermatophyte molds, and yeast (Candida species). More than 90% of cases have this dermatophyte infection, which is mostly brought on by trichophyton rubrum and Candida species. Herbal nail lacquer has been designed and developed in this study for the treatment of onychomycosis. An oleuropein compound found in olive leaves has shown potential as an antifungal agent. Incorporating it into herbal nail lacquer could aim to achieve effective treatment against onychomycosis. It was anticipated that this would increase patient preference as well as potency. The nail lacquer preparation was designed by maceration for extraction and simple mixing and analyzed for thin layer chromatography, gloss, smoothness to flow, viscosity, water resistance test, drying time, and determination of antifungal studies. In this study, the formulation was prepared by using Eudragit RL-100, ethyl acetate, ethyl cellulose, dibutyl phthalate, salicylic acid, acetone, Clitoria ternatea (a coloring agent), and alpha-santalol (a smelling agent). The prepared medicated nail lacquer was evaluated for various parameters such as organoleptic characters, drying time, smoothness of flow, gloss, and water resistance that showed satisfactory results. Among all formulations, the F4 formulation was highly effective due to its good water resistance (0.05 g), quick drying time (60 s), good film thickness (0.14 mm), good viscosity (147 cp), and best zone of inhibition. From the above studies, it can be concluded that medicated nail lacquers proved to be a better tool as a drug delivery system for the transungual drug delivery of an antifungal in the treatment of onychomycosis. It can also be used for the beautification of nails with ease of application.