Published Paper Details:

The purpose of this research is to solve this constraint by designing a transdermal drug delivery system for quercetin that may be administered once daily. This system will provide greater patient compliance, increased bioavailability, and prolonged release compared to other methods. On the other hand, its therapeutic value is restricted due to difficulties associated with poor solubility, low bioavailability, and unpredictable pharmacokinetics when it is administered orally. For the purpose of determining drug flow and permeation parameters, skin permeation experiments are carried out. This is followed by the use of in vitro or in vivo models for the purpose of evaluating the potential for skin irritation caused by the prepared patches. The study aims to achieve several objectives: to formulate a transdermal delivery system capable of sustained release of quercetin over 24 hours. A once-daily transdermal delivery system for quercetin that has sustained release properties is one of the outcomes that is anticipated. The formulation included namely dichloromethane and methanol in a ratio of 1:1, using a method called solvent evaporation. Therefore, linseed oil and eugenol were added to the polymer solution in order to improve the penetration. Polyethylene glycol was employed as a plasticizer, and menthol was added in order to counteract the irritation caused by the polymer. Following the preparation of the films in this manner, they attached to the layer of adhesive bandage that had been acquired from the neighbourhood store.